NFIA
Identifiers
AliasesNFIA, CTF, NF-I/A, NF1-A, NFI-A, NFI-L, nuclear factor I A, BRMUTD
External IDsOMIM: 600727 MGI: 108056 HomoloGene: 4086 GeneCards: NFIA
Orthologs
SpeciesHumanMouse
Entrez

4774

18027

Ensembl

ENSG00000162599

ENSMUSG00000028565

UniProt

Q12857

Q02780

RefSeq (mRNA)

NM_001134673
NM_001145511
NM_001145512
NM_005595

NM_001122952
NM_001122953
NM_010905

RefSeq (protein)

NP_001128145
NP_001138983
NP_001138984
NP_005586

NP_001116424
NP_001116425
NP_035035

Location (UCSC)Chr 1: 60.87 – 61.46 MbChr 4: 97.66 – 98.01 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Nuclear factor 1 A-type is a protein that in humans is encoded by the NFIA gene.[5][6]

Function

Nuclear factor I (NFI) proteins constitute a family of dimeric DNA-binding proteins with similar, and possibly identical, DNA-binding specificity. They function as cellular transcription factors and as replication factors for adenovirus DNA replication. Diversity in this protein family is generated by multiple genes, differential splicing, and heterodimerization.[supplied by OMIM][6]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000162599 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028565 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Qian F, Kruse U, Lichter P, Sippel AE (July 1995). "Chromosomal localization of the four genes (NFIA, B, C, and X) for the human transcription factor nuclear factor I by FISH". Genomics. 28 (1): 66–73. doi:10.1006/geno.1995.1107. PMID 7590749.
  6. 1 2 "Entrez Gene: NFIA nuclear factor I/A".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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