RARG
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesRARG, NR1B3, RARC, retinoic acid receptor gamma, RARgamma
External IDsOMIM: 180190 MGI: 97858 HomoloGene: 20263 GeneCards: RARG
Orthologs
SpeciesHumanMouse
Entrez

5916

19411

Ensembl

ENSG00000172819

ENSMUSG00000001288

UniProt

P13631

P18911

RefSeq (mRNA)

NM_000966
NM_001042728
NM_001243730
NM_001243731
NM_001243732

NM_001042727
NM_011244

RefSeq (protein)

NP_000957
NP_001036193
NP_001230659
NP_001230660
NP_001230661

NP_001036192
NP_035374

Location (UCSC)Chr 12: 53.21 – 53.23 MbChr 15: 102.14 – 102.17 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Retinoic acid receptor gamma (RAR-γ), also known as NR1B3 (nuclear receptor subfamily 1, group B, member 3) is a nuclear receptor encoded by the RARG gene.[5][6] Adapalene selectively targets retinoic acid receptor beta and retinoic acid receptor gamma[7] and its agonism of the gamma subtype is largely responsible for adapalene's observed effects.[8]

Interactions

Retinoic acid receptor gamma has been shown to interact with NCOR1.[9]

See also

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000172819 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000001288 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: RARG retinoic acid receptor, gamma".
  6. Lehmann JM, Hoffmann B, Pfahl M (Feb 1991). "Genomic organization of the retinoic acid receptor gamma gene". Nucleic Acids Research. 19 (3): 573–8. doi:10.1093/nar/19.3.573. PMC 333650. PMID 1849262.
  7. Mukherjee S, Date A, Patravale V, Korting HC, Roeder A, Weindl G (2006). "Retinoids in the treatment of skin aging: an overview of clinical efficacy and safety". Clinical Interventions in Aging. 1 (4): 327–48. doi:10.2147/ciia.2006.1.4.327. PMC 2699641. PMID 18046911.
  8. Michel S, Jomard A, Démarchez M (October 1998). "Pharmacology of adapalene". The British Journal of Dermatology. 139 (Suppl 52): 3–7. doi:10.1046/j.1365-2133.1998.1390s2003.x. PMID 9990413. S2CID 23084886.
  9. Dowell P, Ishmael JE, Avram D, Peterson VJ, Nevrivy DJ, Leid M (May 1999). "Identification of nuclear receptor corepressor as a peroxisome proliferator-activated receptor alpha interacting protein". The Journal of Biological Chemistry. 274 (22): 15901–7. doi:10.1074/jbc.274.22.15901. PMID 10336495.

Further reading

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