ESRRB
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesESRRB, DFNB35, ERR2, ERRb, ESRL2, NR3B2, estrogen related receptor beta, ERRbeta2, ERR beta-2, Esrrb
External IDsOMIM: 602167 MGI: 1346832 HomoloGene: 69108 GeneCards: ESRRB
Orthologs
SpeciesHumanMouse
Entrez

2103

26380

Ensembl

ENSG00000119715

ENSMUSG00000021255

UniProt

O95718

Q61539

RefSeq (mRNA)

NM_004452
NM_001379180

NM_001159500
NM_011934

RefSeq (protein)

NP_004443
NP_001366109

NP_001152972
NP_036064

Location (UCSC)Chr 14: 76.31 – 76.5 MbChr 12: 86.41 – 86.57 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Estrogen-related receptor beta (ERR-β), also known as ESRRB or NR3B2 (nuclear receptor subfamily 3, group B, member 2), is a nuclear receptor that in humans is encoded by the ESRRB (Estrogen Related Receptor Beta) gene .[5]

Function

ESRRB has been shown to be vital for the transition between a naïve pluripotent and primed pluripotent state in mammalian cells, and NANOG controls the expression of ESRRB in this scenario.[6]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000119715 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021255 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: ESRRB estrogen-related receptor beta".
  6. Festuccia N, Halbritter F, Corsinotti A, Gagliardi A, Colby D, Tomlinson SR, Chambers I (November 2018). "Esrrb extinction triggers dismantling of naïve pluripotency and marks commitment to differentiation". The EMBO Journal. 37 (21): e95476. doi:10.15252/embj.201695476. PMC 6213284. PMID 30275266.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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