FOSL2
Identifiers
Aliases	FOSL2, Fos-Related Antigen, FRA-2, FRA2, FOS like 2, AP-1 transcription factor subunit
External IDs	OMIM: 601575 MGI: 102858 HomoloGene: 3845 GeneCards: FOSL2
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p23.2 Start 28,392,448 bp[1] End 28,417,317 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5 B1|5 17.33 cM Start 32,293,145 bp[2] End 32,315,186 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gastric mucosa popliteal artery vagina left uterine tube pericardium gallbladder skin of abdomen canal of the cervix sural nerve human penis Top expressed in mucosa of urinary bladder hair follicle medullary collecting duct conjunctival fornix left colon belly cord ascending aorta epithelium of stomach cumulus cell aortic valve More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity DNA binding chromatin binding protein binding RNA polymerase II transcription regulatory region sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding Cellular component nucleus nucleoplasm Biological process regulation of transcription by RNA polymerase II positive regulation of transcription, DNA-templated keratinocyte development cell death regulation of transcription, DNA-templated transcription, DNA-templated positive regulation of fibroblast proliferation positive regulation of transcription by RNA polymerase II transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2355 14284 Ensembl ENSG00000075426 ENSMUSG00000029135 UniProt P15408 P47930 RefSeq (mRNA) NM_005253 NM_008037 RefSeq (protein) NP_005244 NP_032063 Location (UCSC) Chr 2: 28.39 – 28.42 Mb Chr 5: 32.29 – 32.32 Mb PubMed search [3] [4]
Wikidata
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Fos-related antigen 2 (FRA2) is a protein that in humans is encoded by the FOSL2 gene.^[5]

Function

The Fos gene family consists of 4 members: c-Fos, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation.^[5]

See also

• AP-1 (transcription factor)

References

Further reading

External links

• FOSL2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• FactorBook FOSL2

This article incorporates text from the United States National Library of Medicine, which is in the public domain.