SMAD1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSMAD1, BSP-1, BSP1, JV4-1, JV41, MADH1, MADR1, SMAD family member 1
External IDsOMIM: 601595 MGI: 109452 HomoloGene: 21196 GeneCards: SMAD1
Orthologs
SpeciesHumanMouse
Entrez

4086

17125

Ensembl

ENSG00000170365

ENSMUSG00000031681

UniProt

Q15797

P70340

RefSeq (mRNA)

NM_001003688
NM_005900

NM_008539

RefSeq (protein)

NP_032565

Location (UCSC)n/aChr 8: 80.07 – 80.13 Mb
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Mothers against decapentaplegic homolog 1 also known as SMAD family member 1 or SMAD1 is a protein that in humans is encoded by the SMAD1 gene.[4][5]

Nomenclature

SMAD1 belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. The name is a combination of the two; and based on a tradition of such unusual naming within the gene research community.[6]

It was found that a mutation in the 'Drosophila' gene, MAD, in the mother, repressed the gene, decapentaplegic, in the embryo. Mad mutations can be placed in an allelic series based on the relative severity of the maternal effect enhancement of weak dpp alleles, thus explaining the name Mothers against dpp.[7]

Function

SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed.[8]

SMAD1 is a receptor regulated SMAD (R-SMAD) and is activated by bone morphogenetic protein type 1 receptor kinase.

References

  1. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000031681 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. Hoodless PA, Haerry T, Abdollah S, Stapleton M, O'Connor MB, Attisano L, Wrana JL (May 1996). "MADR1, a MAD-related protein that functions in BMP2 signaling pathways". Cell. 85 (4): 489–500. doi:10.1016/S0092-8674(00)81250-7. PMID 8653785. S2CID 2275955.
  5. Riggins GJ, Thiagalingam S, Rozenblum E, Weinstein CL, Kern SE, Hamilton SR, Willson JK, Markowitz SD, Kinzler KW, Vogelstein B (July 1996). "Mad-related genes in the human". Nature Genetics. 13 (3): 347–9. doi:10.1038/ng0796-347. PMID 8673135. S2CID 10124489.
  6. "Sonic Hedgehog, DICER, and the Problem With Naming Genes", Sep 26, 2014, Michael White. psmag.com
  7. "Interactive fly, Drosophila".
  8. "Entrez Gene: SMAD1 SMAD family member 1".

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