Retinoic acid receptor gamma

RARG
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1EXA, 1EXX, 1FCX, 1FCY, 1FCZ, 1FD0, 2LBD, 3LBD, 4LBD
Identifiers
Aliases	RARG, NR1B3, RARC, retinoic acid receptor gamma, RARgamma
External IDs	OMIM: 180190 MGI: 97858 HomoloGene: 20263 GeneCards: RARG
Gene location (Human)
Chr.	Chromosome 12 (human)
End	53,232,980 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	102,165,952 bp
RNA expression pattern
	Top expressed in
	skin of abdomen; ; stromal cell of endometrium; ; canal of the cervix; ; right coronary artery; ; vagina; ; right uterine tube; ; tibial nerve; ; minor salivary gland; ; right lobe of thyroid gland; ; ascending aorta;
	Top expressed in
	axial skeleton; ; lip; ; vertebral column; ; shoulder; ; ankle; ; vertebra; ; scapula; ; molar; ; rib; ; esophagus;
	More reference expression data
	n/a
Gene ontology
Molecular function	sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; zinc ion binding; metal ion binding; steroid hormone receptor activity; protein binding; DNA-binding transcription factor activity; DNA binding; retinoid X receptor binding; DNA-binding transcription factor activity, RNA polymerase II-specific; transcription cis-regulatory region binding; transcription factor binding; nuclear receptor coactivator activity; signaling receptor activity; nuclear receptor activity;
Cellular component	integral component of membrane; nucleoplasm; nucleus; transcription regulator complex; RNA polymerase II transcription regulator complex;
Biological process	regulation of cell size; growth plate cartilage development; cellular response to retinoic acid; gland development; regulation of transcription, DNA-templated; negative regulation of cartilage development; response to retinoic acid; multicellular organism growth; negative regulation of cell differentiation; bone morphogenesis; chondrocyte development; negative regulation of apoptotic process; retinal pigment epithelium development; transcription, DNA-templated; epithelium development; embryonic camera-type eye development; reproductive structure development; limb development; face development; neural tube closure; negative regulation of chondrocyte differentiation; Harderian gland development; prostate gland epithelium morphogenesis; regulation of myelination; positive regulation of gene expression; retina development in camera-type eye; positive regulation of cell population proliferation; growth plate cartilage chondrocyte growth; canonical Wnt signaling pathway; regulation of gene expression; camera-type eye development; transcription initiation from RNA polymerase II promoter; regulation of myeloid cell differentiation; bone development; trachea cartilage development; anterior/posterior pattern specification; glandular epithelial cell development; steroid hormone mediated signaling pathway; negative regulation of transcription by RNA polymerase II; positive regulation of transcription by RNA polymerase II; embryonic hindlimb morphogenesis; retinoic acid receptor signaling pathway; negative regulation of cell population proliferation; embryonic eye morphogenesis; positive regulation of apoptotic process; positive regulation of programmed cell death; cellular response to leukemia inhibitory factor; multicellular organism development; hormone-mediated signaling pathway; cell differentiation; response to lipid;
	Sources:Amigo / QuickGO
Orthologs
	5916
	19411
	ENSG00000172819
	ENSMUSG00000001288
	P13631
	P18911
	NM_000966; NM_001042728; NM_001243730; NM_001243731; NM_001243732
	NM_001042727; NM_011244
	NP_000957; NP_001036193; NP_001230659; NP_001230660; NP_001230661
	NP_001036192; NP_035374
	Wikidata
View/Edit Human	View/Edit Mouse

Retinoic acid receptor gamma (RAR-γ), also known as NR1B3 (nuclear receptor subfamily 1, group B, member 3) is a nuclear receptor encoded by the RARG gene.^[5]^[6] Adapalene selectively targets retinoic acid receptor beta and retinoic acid receptor gamma^[7] and its agonism of the gamma subtype is largely responsible for adapalene's observed effects.^[8]

Interactions

Retinoic acid receptor gamma has been shown to interact with NCOR1.^[9]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000172819 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000001288 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: RARG retinoic acid receptor, gamma".
↑ Lehmann JM, Hoffmann B, Pfahl M (Feb 1991). "Genomic organization of the retinoic acid receptor gamma gene". Nucleic Acids Research. 19 (3): 573–8. doi:10.1093/nar/19.3.573. PMC 333650. PMID 1849262.
↑ Mukherjee S, Date A, Patravale V, Korting HC, Roeder A, Weindl G (2006). "Retinoids in the treatment of skin aging: an overview of clinical efficacy and safety". Clinical Interventions in Aging. 1 (4): 327–48. doi:10.2147/ciia.2006.1.4.327. PMC 2699641. PMID 18046911.
↑ Michel S, Jomard A, Démarchez M (October 1998). "Pharmacology of adapalene". The British Journal of Dermatology. 139 (Suppl 52): 3–7. doi:10.1046/j.1365-2133.1998.1390s2003.x. PMID 9990413. S2CID 23084886.
↑ Dowell P, Ishmael JE, Avram D, Peterson VJ, Nevrivy DJ, Leid M (May 1999). "Identification of nuclear receptor corepressor as a peroxisome proliferator-activated receptor alpha interacting protein". The Journal of Biological Chemistry. 274 (22): 15901–7. doi:10.1074/jbc.274.22.15901. PMID 10336495.

Leid M, Kastner P, Lyons R, Nakshatri H, Saunders M, Zacharewski T, Chen JY, Staub A, Garnier JM, Mader S (Jan 1992). "Purification, cloning, and RXR identity of the HeLa cell factor with which RAR or TR heterodimerizes to bind target sequences efficiently". Cell. 68 (2): 377–95. doi:10.1016/0092-8674(92)90478-U. PMID 1310259. S2CID 40617478.
Vollberg TM, Nervi C, George MD, Fujimoto W, Krust A, Jetten AM (May 1992). "Retinoic acid receptors as regulators of human epidermal keratinocyte differentiation". Molecular Endocrinology. 6 (5): 667–76. doi:10.1210/mend.6.5.1318502. PMID 1318502. S2CID 35884680.
Lehmann JM, Zhang XK, Pfahl M (Jul 1992). "RAR gamma 2 expression is regulated through a retinoic acid response element embedded in Sp1 sites". Molecular and Cellular Biology. 12 (7): 2976–85. doi:10.1128/mcb.12.7.2976. PMC 364511. PMID 1320193.
Mattei MG, Rivière M, Krust A, Ingvarsson S, Vennström B, Islam MQ, Levan G, Kautner P, Zelent A, Chambon P (Aug 1991). "Chromosomal assignment of retinoic acid receptor (RAR) genes in the human, mouse, and rat genomes" (PDF). Genomics. 10 (4): 1061–9. doi:10.1016/0888-7543(91)90199-O. hdl:1946/20678. PMID 1655630.
Kastner P, Krust A, Mendelsohn C, Garnier JM, Zelent A, Leroy P, Staub A, Chambon P (Apr 1990). "Murine isoforms of retinoic acid receptor gamma with specific patterns of expression". Proceedings of the National Academy of Sciences of the United States of America. 87 (7): 2700–4. Bibcode:1990PNAS...87.2700K. doi:10.1073/pnas.87.7.2700. PMC 53758. PMID 2157210.
Giguère V, Shago M, Zirngibl R, Tate P, Rossant J, Varmuza S (May 1990). "Identification of a novel isoform of the retinoic acid receptor gamma expressed in the mouse embryo". Molecular and Cellular Biology. 10 (5): 2335–40. doi:10.1128/mcb.10.5.2335. PMC 360581. PMID 2157970.
Ishikawa T, Umesono K, Mangelsdorf DJ, Aburatani H, Stanger BZ, Shibasaki Y, Imawari M, Evans RM, Takaku F (Jun 1990). "A functional retinoic acid receptor encoded by the gene on human chromosome 12". Molecular Endocrinology. 4 (6): 837–44. doi:10.1210/mend-4-6-837. PMID 2172793.
Krust A, Kastner P, Petkovich M, Zelent A, Chambon P (Jul 1989). "A third human retinoic acid receptor, hRAR-gamma". Proceedings of the National Academy of Sciences of the United States of America. 86 (14): 5310–4. Bibcode:1989PNAS...86.5310K. doi:10.1073/pnas.86.14.5310. PMC 297611. PMID 2546152.
Renaud JP, Rochel N, Ruff M, Vivat V, Chambon P, Gronemeyer H, Moras D (Dec 1995). "Crystal structure of the RAR-gamma ligand-binding domain bound to all-trans retinoic acid". Nature. 378 (6558): 681–9. Bibcode:1995Natur.378..681R. doi:10.1038/378681a0. PMID 7501014. S2CID 4259376.
Zhou L, Pang J, Munroe DG, Lau C (May 1993). "A human retinoic acid receptor gamma isoform is homologous to the murine retinoic acid receptor gamma 7". Nucleic Acids Research. 21 (10): 2520. doi:10.1093/nar/21.10.2520. PMC 309563. PMID 7685085.
Zitnik RJ, Kotloff RM, Latifpour J, Zheng T, Whiting NL, Schwalb J, Elias JA (Feb 1994). "Retinoic acid inhibition of IL-1-induced IL-6 production by human lung fibroblasts". Journal of Immunology. 152 (3): 1419–27. doi:10.4049/jimmunol.152.3.1419. PMID 8301142. S2CID 20598143.
Botling J, Castro DS, Oberg F, Nilsson K, Perlmann T (Apr 1997). "Retinoic acid receptor/retinoid X receptor heterodimers can be activated through both subunits providing a basis for synergistic transactivation and cellular differentiation". The Journal of Biological Chemistry. 272 (14): 9443–9. doi:10.1074/jbc.272.14.9443. PMID 9083083.
Lømo J, Smeland EB, Ulven S, Natarajan V, Blomhoff R, Gandhi U, Dawson MI, Blomhoff HK (Apr 1998). "RAR-, not RXR, ligands inhibit cell activation and prevent apoptosis in B-lymphocytes". Journal of Cellular Physiology. 175 (1): 68–77. doi:10.1002/(SICI)1097-4652(199804)175:1<68::AID-JCP8>3.0.CO;2-A. PMID 9491782. S2CID 21489004.
Klaholz BP, Renaud JP, Mitschler A, Zusi C, Chambon P, Gronemeyer H, Moras D (Mar 1998). "Conformational adaptation of agonists to the human nuclear receptor RAR gamma". Nature Structural Biology. 5 (3): 199–202. doi:10.1038/nsb0398-199. PMID 9501913. S2CID 30471226.
Zhang ZP, Gambone CJ, Gabriel JL, Wolfgang CL, Soprano KJ, Soprano DR (Dec 1998). "Arg278, but not Lys229 or Lys236, plays an important role in the binding of retinoic acid by retinoic acid receptor gamma". The Journal of Biological Chemistry. 273 (51): 34016–21. doi:10.1074/jbc.273.51.34016. PMID 9852056.
Yang C, Zhou D, Chen S (Dec 1998). "Modulation of aromatase expression in the breast tissue by ERR alpha-1 orphan receptor". Cancer Research. 58 (24): 5695–700. PMID 9865725.
Nagpal S, Ghosn C, DiSepio D, Molina Y, Sutter M, Klein ES, Chandraratna RA (Aug 1999). "Retinoid-dependent recruitment of a histone H1 displacement activity by retinoic acid receptor". The Journal of Biological Chemistry. 274 (32): 22563–8. doi:10.1074/jbc.274.32.22563. PMID 10428834.
Egea PF, Mitschler A, Rochel N, Ruff M, Chambon P, Moras D (Jun 2000). "Crystal structure of the human RXRalpha ligand-binding domain bound to its natural ligand: 9-cis retinoic acid". The EMBO Journal. 19 (11): 2592–601. doi:10.1093/emboj/19.11.2592. PMC 212755. PMID 10835357.
Boudjelal M, Voorhees JJ, Fisher GJ (Mar 2002). "Retinoid signaling is attenuated by proteasome-mediated degradation of retinoid receptors in human keratinocyte HaCaT cells". Experimental Cell Research. 274 (1): 130–7. doi:10.1006/excr.2001.5450. PMID 11855864.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000172819 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000001288 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: RARG retinoic acid receptor, gamma".

[pmid1849262-6] Lehmann JM, Hoffmann B, Pfahl M (Feb 1991). "Genomic organization of the retinoic acid receptor gamma gene". Nucleic Acids Research. 19 (3): 573–8. doi:10.1093/nar/19.3.573. PMC 333650. PMID 1849262.

[pmid18046911-7] Mukherjee S, Date A, Patravale V, Korting HC, Roeder A, Weindl G (2006). "Retinoids in the treatment of skin aging: an overview of clinical efficacy and safety". Clinical Interventions in Aging. 1 (4): 327–48. doi:10.2147/ciia.2006.1.4.327. PMC 2699641. PMID 18046911.

[pmid9990413-8] Michel S, Jomard A, Démarchez M (October 1998). "Pharmacology of adapalene". The British Journal of Dermatology. 139 (Suppl 52): 3–7. doi:10.1046/j.1365-2133.1998.1390s2003.x. PMID 9990413. S2CID 23084886.

[pmid10336495-9] Dowell P, Ishmael JE, Avram D, Peterson VJ, Nevrivy DJ, Leid M (May 1999). "Identification of nuclear receptor corepressor as a peroxisome proliferator-activated receptor alpha interacting protein". The Journal of Biological Chemistry. 274 (22): 15901–7. doi:10.1074/jbc.274.22.15901. PMID 10336495.

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[4]

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[6]

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[9]

Retinoid receptor modulators
RAR	Agonists: 9CDHRA 9-cis-Retinoic acid (alitretinoin) AC-261066 AC-55649 Acitretin Adapalene all-trans-Retinoic acid (tretinoin) AM-580 BMS-493 BMS-753 BMS-961 CD-1530 CD-2314 CD-437 Ch-55 EC 23 Etretinate Fenretinide Isotretinoin Palovarotene Retinoic acid Retinol (vitamin A) Tamibarotene Tazarotene Tazarotenic acid Trifarotene TTNPB Antagonists: BMS-195614 BMS-493 CD-2665 ER-50891 LE-135 MM-11253 Retinoic acid metabolism inhibitors: Liarozole
RXR	Agonists: 9CDHRA 9-cis-Retinoic acid (alitretinoin) all-trans-Retinoic acid (tretinoin) Bexarotene CD 3254 Docosahexaenoic acid Fluorobexarotene Isotretinoin LG-100268 LG-101506 LG-100754 Retinoic acid Retinol (vitamin A) SR-11237 Antagonists: HX-531 HX-630 LG-100754 PA-452 UVI-3003 HX-603 LE135 (RAR beta selective) LE-540 CD3254 PA-451 PA-452 Rhein HX-711 6-(N-ethyl-N-(5-isobutoxy-4-isopropyl-2-(E)-styrylphenyl)amino)nicotinic acid
See also Receptor/signaling modulators

Interactions

See also

References

Further reading